Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS)

M A Curtis; V Varkhedkar; P V Pragnacharyulu; E Abushanab

doi:10.1016/s0960-894x(98)00291-1

Adenosine deaminase inhibitors. Synthesis and biological evaluation of aralkyladenines (ARADS)

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1639-42. doi: 10.1016/s0960-894x(98)00291-1.

Authors

M A Curtis¹, V Varkhedkar, P V Pragnacharyulu, E Abushanab

Affiliation

¹ Department of Biomedical Sciences, University of Rhode Island, Kingston 02881-0809, USA.

PMID: 9873405
DOI: 10.1016/s0960-894x(98)00291-1

Abstract

Several 9-aralkyladenines have been prepared and their ADA inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the adenine-bearing carbon (C3') was found essential for potent activity.

MeSH terms

Adenine / analogs & derivatives
Adenine / chemical synthesis*
Adenine / pharmacology*
Adenosine Deaminase Inhibitors*
Drug Evaluation
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*

Substances

Adenosine Deaminase Inhibitors
Enzyme Inhibitors
Adenine